Preoperative pregabalin does not reduce propofol ED50: a randomized controlled trial

Pantoprazole Does Not Reduce the Antiplatelet Effect of Clopidogrel: A Randomized Controlled Trial in Korea

Background/Aims Concerns that proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel could hamper the appropriate prescription of PPIs. We evaluated the influence of pantoprazole on the antiplatelet effect of clopidogrel compared with ranitidine, which is regarded as safe, after stratification of the population according to the presence of a cytochrome (CYP) 2C19 polymorphism in Kor...

Non-Pharmacological Intervention to Reduce Sleep Disturbance among Older adults: A Randomized Controlled Trial Study

Aim: This study aimed to determine the effect of folk music intervention and sleep hygiene education on the sleep quality of the older adults. Participants and Methods: This was a randomized controlled trial (RTC) that investigated the effect of music and sleep- hygiene on sleep disturbance among the elderly in Urmia. The study population consisted of 150 elderly people covered by Urmia compre...

Enhanced Ovarian Folliclular Development by Metformin Does Not Correlate with Pregnancy Rate: A Randomized Trial

Preoperative ondansetron does not reduce the incidence of maternal hypotension during elective caesarean delivery under spinal anaesthesia, but mitigate its severity: a double blind, randomized, placebo controlled trial

Background. The prophylactic administration of ondansetron has been reported to provide a protective effect against hypotension in spinal anaesthesia (SA). Material and methods. This prospective double-blind, randomised, placebo-controlled study included 130 healthy pregnant women scheduled for elective caesarean delivery under SA randomly allocated to receive placebo (n = 65) or ondansetron 8 ...

Does Topical Anesthetic Reduce Pain During Intraosseous Pin Removal in Children? A Randomized Controlled Trial.

BACKGROUND The purpose of this study was to determine the effectiveness of topical liposomal lidocaine in reducing the pain perceived by children undergoing percutaneous intraosseous pin (PP) removal in the outpatient orthopaedic clinic. METHODS A triple-blinded, randomized, placebo-controlled clinical trial comparing topical liposomal lidocaine to a placebo was conducted at the Stollery Chil...